Results of structurally optimum circuit diagram designing of the radiation-resistant instrumentation amplifier on the base of the paraphase multidifferential operational amplifier possessing high metrological properties in the conditions of radiating influence are considered. It is shown that use of such instrumentation amplifier allows receiving high quality indicators at influence of scale of destabilizing factors. Results of modeling of such tool amplifier realized on components of a radiation-resistant analog base matrix crystal are resulted.